GABAergic interneurons are essential components of neural circuits and are crucial in nearly all aspects of neural computation.  The large diversity of interneuron cell types provides the rich variety and fine details of inhibition, which confers the balance, complexity, and functional architecture of neural network.  My laboratory combines mouse genetic engineering, imaging, electrophysiology to study the development, function and plasticity of GABA inhibitory circuits in neocortex and cerebellum.  We currently focus on the following areas: 1) developing genetic tools to systematically visualize and manipulate all major classes of GABAergic neuron, 2) mechanisms underlying the subcellular organization different classes of GABAergic synapses; 3) activity-dependent plasticity of GABAergic synapses; 4) role of GABA inhibition in the critical period of experience dependent plasticity. 

 

Supported by NIH, Pew Charitable Trust, McKnight Foundation, EJLB Foundation, Mathers Foundation, Simons Foundation, Whitehall Foundation, HFSP, EMBO, NARSAD, Cold Spring Harbor Laboratory

Please send academic inquiries directly to Josh Huang.